How Do Hemp Essential Oil & CBD Isolates Work?

Essential Oils UK

In order to understand how Hemp Essential Oil and CBD isolates work, we first need to understand how the Endo Cannabinoid System works.

We also need to distinguish the differences between Hemp Essential Oil, CBD Oil & CBD isolates, which are used in the treatment of a large number of acute and chronic inflammatory conditions.

Copaiba Essential Oil also interacts with our endocannabinoid system, just like Hemp Essential Oil and CBD. This is also true of Cananga Essential Oil.

This article will cover all of these topics, as well as a whole lot more…

Additional information

Hemp Essential Oil FAQ

Hemp Essential Oil In Brief

Copaiba Essential Oil In Brief

Cananga Essential Oil

If you suffer from chronic inflammatory pain / autoimmunity then this is a must read: Mast Cell Activation Syndrome.

Endocannabinoid System

The Endocannabinoid System has been getting a lot of air play due to everyone singing the praises of CBD Oil, aka Hemp Essential Oil, in the press.

But, despite increasing awareness, there doesn’t seem to be a whole lot of understanding about what the Endocannabinoid System actually is, and therefore how Hemp Essential Oil, Copaiba Essential Oil or CBD Oil, actually works.

This article is designed to change all that.

What Is The Endocannabinoid System?

The Endocannabinoid System is a messenger system which works throughout our entire body and connects the brain, the gut, neurological system, the immune system, and the endocrine system.

It was only discovered in the 1990’s despite it being a body-wide system which is so important to our wellbeing.

Endocannabinoid System Receptors

There are two main Endocannabinoid receptors that we know about, but we are discovering more all the time.

They are called CB1 and CB2.

CB1 Receptors

CB1 Receptors are located primarily in the brain and connect with things like the Hippocampus, which deals primarily with memory. When we are under stress the Hippocampus shrinks, which in turn inhibits recall.

This is why people with food allergies, (which stress out the gut), and autoimmune diseases, may suffer from brain fog and memory loss. However, leaky gut also plays a large part in these scenarios.

You can read more about this in Stress is The Cause Of All Illness

CB1 Receptors also connect with the Amygdala, which governs the fight or flight response and is where PTSD issues occur. Other emotions, like anger also flare up in the Amygdala.

This is unsurprising as the Amygdala is all about primeval survival.

CB1 Receptors also connect to the Basal Ganglia, for motor functioning, the Cerebellum, for balance and coordination, the Nucleus Accumbens, which is all about reward, (and therefore addiction, which CBD is being used to treat), and the Cortex / Frontal Lobe, which is responsible for executive function, (which is effectively summed up as mature thoughts and actions).

The Frontal Lobe is offline in children.

Hemp Essential Oil, as well as CBD Oil interact with CB1 receptors.

The CB2 Receptors

The CB2 Receptors are all in the peripheral organs and immune system with a lot of them residing in the gut.

Copaiba Essential Oil, Cananga Essential Oil and Hemp Essential Oil, as well as CBD Oil interact with CB2 receptors.

What Are Endocannabinoids & Endocannabinoid Receptors?

We make endocannabinoids ourselves in the form of Anandamides and 2AG. Anybody who has read any of the Endocrine System articles in the Hormone Health series will know that hormones are chemical messengers, just like neurotransmitters. We all have them, and they deliver messages throughout our bodies in order to maintain homeostasis… in other words —> a healthy balance.

Receptors are where our chemical messengers dock. So the CB1 and CB2 Receptors are the docking stations for the endocannabinoids we produce.

***The endo element of endocannabinoids relates to them being an hormonal system, and this is why they behave as chemical messengers and need the CB1 and CB2 receptors to deliver their messages. Hormones and Neurotransmitters are both chemical messengers and they need receptor sites through which to deliver their messages also.

What Does The Endocannabinoid System Do?

The Endocannabinoid System affects gastrointestinal motility and we are more likely to contract IBS if the Endocannabinoid System is defective in some way. It also controls nausea and vomiting and visceral sensations like stomach ache.

Because stress is mediated by the Endocannabinoid System, which adversely affects the gut if the Endocannabinoid System is in any way compromised, we end up with a stomach ache.

***Nikki, from Surrey, has successfully reversed all of her IBS symptoms, which she has had for 30 years after using Organic Nigella Sativa Oil. Nigella Sativa is not a Cannabinoid oil, but is referred to as “the cure for everything but death”.

We react to stress through the Hypothalamus, Pituitary and Adrenal Axis, aka HPA Axis, and the Endocannabinoid System tends to tone the HPA Axis down to protect us from stress. By interacting with the HPA Axis in this way the Endocannabinoid System is also signalling to the GI tract to calm down.

People who don’t have enough Endocannabinoid activity are the ones who are more likely to suffer from PTSD as well as IBS.

How Do Hemp Essential Oil & CBD Isolates Work?

Hemp Essential Oil & CBD isolates boost levels of endocannabinoids within our bodies, thereby reducing pain and anxiety etc.

*Pain relief and the reduction in symptoms of anxiety and depression are the two most common reasons why people take Hemp Essential Oil or CBD. It is often people who have deficiencies in their endocannabinoid system who suffer from these symptoms.

*However, there is mounting anecdotal evidence suggesting that using CBD can make anxiety conditions worse. **There are also other helath concerns – please see below.

Hemp Essential Oil and CBD have also been very successfully used to assist people coming off heavily addictive pharmaceutical drugs, like psychiatric and mood modulating drugs, such as anti-depressants. Many anti-depressants, including the very commonly prescribed SSRI’s, not only have ‘suicidal thoughts’ as a known side effect, but are extremely addictive as well.

Hemp Essential Oil will help with both the suicidal tendencies as well as helping people ween themselves off these unhelpful drugs.

*Anti-depressants have only been proven to be 5% effective and the manufacturers claim that they take months to start working. Almost all people suffering from depression will recover in a matter of a couple of months, but the ones who take the SSRI’s could well have formed a dependancy to these drugs, which will make for a pretty horrendous withdrawal process.

Hemp Essential Oil and CBD isolate can both be used to support the withdrawal process from pharmaceutical drugs as well as recreational street drugs, like Heroine and other, more dangerous opioids, such as Fentanyl and Oxycontin, both of which are pharmaceutical drugs which now have an impressive street value.

***Most cases of Heroine addiction start with an addiction to these pharmaceutical opioids.

Learn more about mental health issues and the terrible track record of anti-depressants.

Learn more about Fentanyl and Oxycontin street use epidemic which is arriving on our shores from America.

CBD Isolate Health Concerns

The positive outcomes from using CBD Isolates mentioned in this article relate to clincal grade CBD Oil, and not commercially available CBD Oil.

Sadly, there has been a worrying increase in adverse events, and even death, as a consequence of taking commercially available CBD Oil

Four people nearly die after taking synthetic CBD

There is a growing use of novel psychoactive substances containing synthetic cannabinoids…  These synthetic drugs replicate the effects of natural cannabis… but they induce more severe adverse effects including respiratory difficulties, hypertension, tachycardia, chest pain, muscle twitches, acute renal failure, anxiety, agitation, psychosis, suicidal ideation, and cognitive impairment. Chronic use of synthetic cannabinoids has been associated with serious psychiatric and medical conditions and even death.

NIH.Gov (National Institute of Health)

Hemp Essential Oil Concerns?

It has come to my attention, mainly from customer feedback, that certain ‘big brand’ Hemp Essential Oils, purchased off the UK High Street, as well as online, have provided no benefit when taken as instructed.

In certain instances, customers have almost certainly been referring to CBD isolates when making this comparison.

A lot of these Hemp and CBD products originate from overseas.

Hemp Essential Oil UK

Sadly, the UK Hemp Essential Oil sector is also not as scrupulous as I’d like… It is very rare to find a completely natural and unmodified UK Hemp Essential Oil.

Wild As The Wind Hemp Essential Oil is only one of a handful of pure, unadulterated UK Hemp Essential Oils available, despite there being a plethora of options.

However, it’s not all bad news… The Wild As The Wind Hemp Essential Oil is one of the most affordable genuine Hemp Essential Oils in the UK… so you are one of the ones who has landed lucky online…

Hemp Essential Oil Versus CBD

Hemp Essential Oil is a full-spectrum Endocannabinoid product whereas CBD, or Canabidiol, is an isolate of Hemp Essential Oil.

Big Pharma tends to work with isolates, and more often than not these isolates are synthetic. We are increasingly beginning to realise the use of isolates is often really not good for us.

Pharmaceuticals, taken as prescribed, are known to be the third biggest killer worldwide.

There are over 100 cannabinoids in Hemp Essential Oil. All of these 100+ cannabinoids are needed for the proper assimilation of Hemp Essential Oil after it has been taken orally or applied topically.

Only when Hemp Essential Oil is properly ingested can the true benefits be achieved. And, only full spectrum Hemp Essential Oil can be ingested effortlessly.

This is called the entourage effect, which is essentially the synergistic effect of all of these constituents working together to allow the Hemp Essential Oil to be thoroughly metabolised.

In addition, Hemp Essential Oil contains other important constituents, like terpines, which have broad spectrum medicinal applications also.

Unfortunately, you need huge amounts of CBD isolate to be effective when it is being used as a single constituent. But, it is used in much smaller and more effective dosages when used as part of Hemp Essential Oil.

Unfortunately, people believe that the CBD isolate is better on it’s own because it is what is used for research purposes. But, the only reason cannabidiol is used on it’s own in research is because it can be accurately measured, whereas, Hemp Essential Oil will differ from one batch to another and from one production region to another.

Different growing conditions for the Cannabis plant will result in variations in quality and constituent quantities. The weather, soil quality and the amount of pollution will all play a part in the quality of the plant material used in making Hemp Essential Oil, and, because Cannabis plants grow ten feet in ten weeks they pull absolutely everything out of the soil.

This means that Cannabis grown near energy generating plants, where fossil fuels have been burnt for electricity generation are much more likely to contain heavy metals, which are extremely toxic to the body.

If herbicides or pesticides are used in the growing of the plants this will also mean high levels of toxicity.

So, if you want a CBD oil that will work and not have any nasty side effects, you need a full-spectrum Hemp Essential Oil which Is grown without pesticides, in a clean air region.

Wild As The Wind Hemp Essential Oil is one such full-spectrum CBD oil, which also happens to be the only UK grown Hemp Essential Oil which is Home Office approved.

CBD & Hemp Essential Oil Dosage

Dosage ranges for CBD isolate are much higher than those needed for Hemp Essential Oil.

Well known studies have used as much as 600mg of CBD isolate to achieve good results, such as the social anxiety study with public speaking participants, which is often used to illustrate the efficacy of CBD isolate.

However, when CBD is found in its natural state, amid all of the allied, naturally occurring, cannabinoids found in Hemp Essential Oil, these excessive and costly doses are just simply not required.

Hemp Essential Oil Is Beneficial For Many Conditions

Hemp Essential Oil is great for sleep disorders, anxiety issues, depression, PTSD, gastro-intestinal disorders, pain and hormonal problems.

According to Dr Eric Zielinski: Modern research shows that the compounds in Cannabis can:

  • Reduce pain (analgesia).
  • Help reduce side-effects related to chemotherapy in cancer patients (especially pain and vomiting).
  • Reduce muscle spasms and neurological overactivity in MS and cerebral palsy patients.
  • Help reduce ocular pressure in glaucoma patients.
  • Lower blood pressure.
  • Relieve symptoms of asthma, constipation, depression, epilepsy and insomnia.

While we don’t know precisely the reason why Cannabis is such an effective healing agent it’s theorized to be because it contains “an enormous variety of chemicals. Some of the 483 compounds identified are unique to Cannabis, for example, the more than 60 cannabinoids, whereas the terpenes, with about 140 members forming the most abundant class, are widespread in the plant kingdom.” It can also be a synergistic effect of these compounds working together.

I also include the list of medical websites which list all the research proving that Cannabis is healing Cancer.

Contraindications of CBD Or Hemp Essential Oil

The P450 enzyme system in the Liver is the one which detoxes CBD and Hemp Essential Oil, and so, if people using Hemp Essential Oil or CBD isolate are also on pharmaceutical drugs which use the same detox pathway, then this could theoretically increase the dose of the pharmaceutical drug in some cases.

This is a lot more likely to happen if using a CBD isolate, but unless doses of over 100mg are being used of Cannabidiol / CBD isolate, then there is very little risk of any adverse effects.

Higher dosages of CBD isolate are also much more likely to exacerbate the problem rather than solve it because of the biphasic curve which denotes efficacy.

This curve determines low dosages of CBD isolate don’t work, mid-range dosages to higher dosages can be effective, but if you go too high, conditions like anxiety will actually become worse, rather than better.

The chances of giving the wrong dose with Hemp Essential Oil is practically non-existent because Hemp Essential Oil is effective at much lower dosages owing to it being a complex.

Hemp Essential Oil Dosage

Hemp Essential Oil is needed in the quantity you personally require depending on how effective your own Endocannabinoid System is. The weaker or more depressed your own Endocannabinoid System is, the more Hemp Essential Oil you will need to take.

Stress is the precursor for dosage. As a rule pf thumb we will need more Hemp Essential Oil the more stress we are under.

*Sometimes our anxiety issues are caused by insufficient Tryptophan or Gaba, so supplementing with Tryptophan and Gaba may be enough. But, supplementing with Hemp Essential Oil will also help us to increase our natural levels of hormones like Gaba and will similarly have a positive effect on the efficacy of our natural levels of Tryptophan.

Hemp Essential Oil also works in tandem with Seretonin, the neurotransmitter responsible for establishing how happy we are. CBD in Hemp Essential Oil actually modulates Seretonin, because our Endocannabinoid System works in tandem with our Seretonin levels. Bumping up our Endocannabinoids therefore improves ore Seretonin function.

Vaping Hemp Essential Oil is great for acute pain and migraines, although I personally like Frankincense for migraines… Frankincense Essential Oil has a good amount of Terpines also.

Hemp Essential Oil & Cancer

The following list of research has been doing the rounds within various blog posts, but I found it within an Eric Zielinski article.

Biliary Tract Cancer

Bladder Cancer

Blood Cancer

Brain Cancer

Breast Cancer

Colorectal Cancer

Liver Cancer

Lung Cancer

Non-Specific Cancers

Oral Cancer

Ovarian Cancer

Prostate Cancer

Skin Cancer

Uterine, Testicular, and Pancreatic Cancers

Additional information

Hemp Essential Oil FAQ

Hemp Essential Oil In Brief


The information provided is not intended to replace the medical directives of your healthcare provider. This information is not meant for the diagnosis of health issues. If you are pregnant, have serious or multiple health concerns, consult with your healthcare provider before using essential oils or associated products. If you experience any complications or adverse reactions contact your healthcare provider.

Deepen your knowledge by using the Wild As The Wind Recommended Resources

Another resource you may find useful can be found by following the link below. *Please note, I use sources from the Recommended Resources list as well as sources from the Healthcare and Skincare Information Sources list when researching articles for the Wild As The Wind Blog.

Best Healthcare and Skincare Information Sources.

Wild As The Wind use a number of resources when deciding which essential oil formulas to put together for optimal healing and efficacy, as well as to support any health claims we may make.

We use the industry ‘bible’ on essential oil safety: Essential Oil Safety: A Guide for Health Care Professionals [2nd Edition] by Robert Tisserand and Rodney Young, to establish the safety of the Wild As The Wind formulations.

We owe a particular debt to Hyla Cass for her tireless work with Hemp Essential Oil as well as GreenMedInfo, and, of course, the teachings of Penny Price and Patricia Davis.

Many of the scientific studies used to inform the claims made on this website are via GreenMedInfo, as well as via Dr. Josh Axe, Ty Bollinger on the Truth About Cancer website as well as, on the odd occasion, Dr. Eric Zielinski

Other resources include:

  • PubMed
  • WebMD
  • Robert Tisserand
  • Dr. Robert Pappas
  • AromaWeb


About Rachel Wild

Rachel Wild is the Creative Director at Wild As The Wind. She's been a professional writer for print and digital publication for more years than she cares to remember. She is no longer a 'writer for rent', now very gratefully, devoting all of her time to her passion... writing about health and well-being and sharing it as far and wide as she can. (Please help her!)

Rachel passionately supports creative endeavour and independent thinking. "The future, if it's good, will see a triumph of quality over quantity, substance over style and give rise to truly inspired thinking born of fearlessness and compassion."

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